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Uterine serpin
Uterine serpins are members of the A clade of the serine proteinase inhibitor (serpin) superfamily of proteins and are encoded by the SERPINA14 gene. Uterine serpins are produced by the uterine endometrium of a restricted group of mammals under the influence of progesterone or estrogen. These proteins appear to be inactive proteinase inhibitors and may function during pregnancy to regulate immune function or participate in transplacental transport.
== Nomenclature ==
Uterine serpins were originally described in the uterine secretions of unilaterally-pregnant sheep as a pair of 57 kDa and 55 kDa glycoproteins. Termed uterine milk proteins (UTMP), their identification as members of the serpin superfamily was based on sequencing of the cDNA for the sheep gene. The pig uterine serpin was first identified because of its association with an iron-binding uterine protein termed uteroferrin. and was originally termed uteroferrin-associated protein.
The designation of uterine serpins as SERPINA14 is based on their classification as a highly-divergent group of the α1-antitrypsin or A clade. In other analyses, uterine serpins have been considered as a separate clade in the serpin superfamily.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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